科學技術-科研成果

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的生物藥

科學論文

Xie Y T , Zhang L , Hou W L ,et al.A novel method for monitoring N-nitrosamines impurities using NH2-MIL-101(Fe) mediated dispersive micro-solid phase extraction coupled with LC-MS/MS in biopharmaceuticals.[J].Journal of pharmaceutical sciences, 2023.DOI:10.1016/j.xphs.2023.07.017.
Journal of Pharmaceutical Sciences
Wang L, Xie L, Zhang Z. Determination of HER2 binding domain in antigen-antibody complexes based on chemical crosslinking mass spectrometry. J Proteomics. 2023 Aug 30;286:104954. doi: 10.1016/j.jprot.2023.104954. Epub 2023 Jun 28. PMID: 37390893.
Journal of Proteomics
Liu Z, Cao Y, Zhang L, et al. In-Depth Characterization of mAb Charge Variants by On-Line Multidimensional Liquid Chromatography-Mass Spectrometry. Anal Chem. 2023 May 23;95(20):7977-7984. doi: 10.1021/acs.analchem.3c00791. Epub 2023 May 12. PMID: 37170561.
Analytical Chemistry
Preclinical activity of HLX43, a PD-L1-targeting ADC, in multiple PD-1/PD-L1 refractory/resistant models.
ESMO 2023
Preclinical evaluation of HLX42, a novel EGFR-targeting ADC, for Cetuximab or TKI resistant cancer.
ESMO 2023
HLX208, a novel BRAF V600E inhibitor, in adult patients with Langerhans cell histiocytosis and/or Erdheim-Chester disease harbouring BRAF V600E mutation
ESMO Asia 2023

知識產權

專利申請數量	PCT申請數量	國內外授權專利數量	註冊司法權區	申請日期	到期日	發明專利數量
809	90	134	中國大陸	2011-03-18	2031-03-18	97

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